AN EFFICIENT BIO ACTIVE SYNTHESIS OF N-SUBSTITUTED ACRIDINE ANALOGOUS
L. Rama Lakshmi, B. Pryanka and Dr. N. Krishna Rao*
ABSTRACT
The highly versatile and an efficient synthesis of N-alkyl derivatives of acridine 10-benzyl-9-(3,4-dimethoxyphenyl)-3,3,6,6-tetramethyl-3,4,6,7,9,10-hexahydroacridine-1,8(2H,5H)-dione is by obtained from 9-(4-bromophenyl)-3,3,6,6-tetramethyl-3,4,6,7,9,10-hexahydroacridine-1,8(2H,5H)-dione with substituted (bromomethyl) benzene which is also three component cyclocondensation of 1,2-dicarbonyl compounds like dimedone, bromo benzaldehyde and ammonium chloride in the presence KIO4 solvent free condition. All the compounds were confirmed by advanced spectroscopic data (1H NMR, 13C NMR& LCMS) and the structural determination of the novel derivations was calculated by elemental analysis. In the present study, ten hybridized imidazoles derivatives were synthesized via cyclo condensation and evaluated for their invitro antimicrobial activity.
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