Abstract

Ashok Kumar Sharma*, Heena Sharma, Yash Soni, Ritika Tak, Ankit Jangid and Shafin Khan

ABSTRACT

Codeine is a narcotic drug that exhibits central activity by blocking the medullary cough centre or inhibiting nerve transmission to the muscles responsible for coughing. As a result, many studies have been conducted by scientists to understand the mechanisms of codeine. These studies show that "RAR" or "COUGH RECEPTOR "is sensitive to codeine, but coughs triggered by neurokinin-containing nociceptive nerves are resistant to it. To address this disease, experts recommend combining codeine with an NK2 tachykinin. Yet another study Demonstrate the activity of codeine's antitussive property in URTI-induced cough. The research included 82 people with acute URTI-related cough (51 women and 31 men; mean age 23.5 years; range 18-46 years). The research was carried out across two separate study days. The study's findings indicate that codeine is neither more nor less effective in the treatment of UTRI-induced cough. A study is now underway to test the antitussive properties of codeine on the tracheal bifurcation. This study found that cough caused by mechanical stimulation of the larynx is more responsive to codeine administration than cough caused by mechanical stimulation of the tracheal bifurcation. Tulsi Ocimum sanctum, Lamiaceae family, popularly known as "HOLY PLANT" has several medical properties such as antibacterial, antifungal, antitussive, and so on. A study is being conducted by scientists to determine the active elements responsible for the antitussive properties of ocimun sanctum. Another research found that Tulsi leaves had significant amounts of camphene, eugenol, and cineole, which assist in the treatment of cough, asthma, and other conditions. This page contains a comprehensive discussion on the use of codeine and ocimun sanctum in the treatment of acute cough, chronic cough, and disease-induced cough.