Abstract

Harshit Gupta*, Ms. Ragini Bundela, Dr. Sourabh Jain and Dr. Karunakar Shukla

ABSTRACT

To get beyond the inherent constraints of both injections and patches, microneedle transdermal patches combine hypodermic needles with transdermal patches. There is an urgent need for a non-invasive delivery system to take the place of the injection currently utilized for low molecular weight heparin (LMWH) multi-dose therapy. In this work, a microneedle mould was made utilizing a 3M microneedle and unsaturated polyester resin and peroxide. The active ingredient, 20 mg (IU) of low molecular weight heparin (LMWH), was combined with 20% w/v polymers of PVA and PVP (polyvinyl alcohol and polyvinyl pyrrolidone) to create a transdermal patch that dissolves microneedle arrays. By using infrared spectroscopy to examine the physicochemical compatibility of the medication and the polymers, it was determined that there was no incompatibility. The physical properties of developed transdermal films were assessed, including weight variation, medication content, folding endurance, moisture content %, and water uptake. Good physical stability was indicated by all produced formulations. Using Franz diffusion cells, in vitro formulation permeation investigations were carried out. In comparison to all other formulations, the one made with PVP: PVA 1:2 showed the best ex-vivo skin penetration through Wistar rat skin. A diffusion mechanism controlled the penetration of the medication from the patches, according to the release profile of the improved formulation F2 (R2 = 0.9933 for Higuchi). The creation of microneedle transdermal patches for LMWH was successful, and subsequent analysis of these patches indicated that they may find use in the therapeutic field, providing benefits such as efficient non-invasive administration with increased patient compliance and bioavailability.