Abstract

*Krishan Kishore Badoniya, Shubham K. Vishwakarma and Seerat Anwar

ABSTRACT

Nanotechnology, where nano signifies incredibly minute structures ranging from 1 to 100 nm, can be defined as the characterization, fabrication, investigation, and application of nanosized materials. Various nano particles offer certain unique advantages as pharmaceutical delivery systems, which is one of the emerging approaches for using nanotechnology successfully in medicine. A rapidly expanding topic, the creation of non-biodegradable nanoparticles is essential for both nanotechnology and nanomedicine applications. Our focus in this inquiry will be on creating and analyzing silver nanoparticles that have been loaded with metronidazole for antibacterial purposes. The metronidazole-loaded silver nanoparticles were created using conventional chemical reduction techniques. We investigated the metronidazole-loaded silver nanoparticles using zeta potential, TEM, in vitro release kinetics and photo correlation spectroscopy (PCS). The resulting elements were globular, with average particle sizes of 5 to 20 nm, and had zeta potentials ranging from -25.9 to -37.3 mV. The release kinetics were in accordance with zero order kinetics, and r2 was greater than 0.94. According to the dissolution data, the release of the Ag-nanoparticles that are loaded with metronidazole is inversely related to the dimension of the nanoparticles, or the release is enlarged with lesser elements. The consequences propose that the metronidazole-loaded nanoparticles (NPs) would be constant in p’ceutical formulations and with no trouble absorbed at the disease site. The antibacterial properties of the silver nanoparticles with metronidazole were shown to be particularly potent against a wide variety of microorganisms. Salmonellae, S. coccus, and E. coli were the bacteria that were investigated.