Abstract

Chinthaginjala Haranath, Abul Hassan Junaid*, Pullaganti Sai Sree

ABSTRACT

There have been numerous initiatives in recent years to increase drug absorption rates and the therapeutic effectiveness of oral dosage forms. By employing gastroretentive drug delivery systems, it is possible to overcome the major drawbacks of conventional drug delivery methods, including their short residence time, unpredictable absorption, and lack of control over drug release. These systems are useful tools for enhancing medication therapy because they have the potential to increase drug absorption, bioavailability, patient compliance, and consistent therapeutic effects. One of these methods for extending gastric residence time is gastroretentive drug delivery, which targets site-specific drug release in the stomach for local or systemic effects. The distinct evaluation criteria for the gastroretentive systems vary depending on the dosage types. The selection of a drug for use in gastro-retardant systems must meet a number of requirements, including restricted absorption, sparingly stability, and compatibility with the gastrointestinal region. In addition to discussing the synthetic polymers utilized in the formulation and marketed products, this review emphasizes the numerous pharmacological strategies for gastroretention such as floating drug delivery systems, mucoadhesive systems, high-density systems, expandable and swelling systems, ion exchange resin system and recent patents filed or granted for this approach.