Abstract

Mohammed Sajas Siraj*, Viresh K Chandur and A.R. Shabaraya

ABSTRACT

Spray drying is a closed, one-phase process that allows us to convert a liquid input product into a solid output product. (Solution, suspension, and rarely emulsion). It is widely employed technique for the production of microsphere, which are extensively used in industries such as pharmaceuticals, cosmetics etc. The process involves atomizing a liquid feed into small droplets, which are subsequently dried to form solid microsphere. The successful application of spray drying relies on optimizing various system parameters to achieve desire product characteristics. This review article provides a comprehensive overview of the influence of system parameters, including feed rate, feed concentration, inlet temperature, drug polymer ratio etc. on the spray drying process of microsphere. It has been demonstrated that a higher nozzle air pressure boosts manufacturing yield without any prior justification The air-drying temperature is crucial for particle size and recovery. The size, dispersion, and velocity of the droplets are affected by the feed injection rate. The feed concentration has a fairly small impact on droplet size. When the air flow rate was decreased, it appeared that the particle size increased. Increasing the drug to polymer ratio was also observed to marginally enhance the size of the microspheres.