Abstract

*Dr. Jagpal Singh, Dr. Girendra Kumar Gautam, Dr. Ashok Kumar and Jonny Kumar

ABSTRACT

The manipulation of diabetes mellitus on Endothelial Dysfunction is not clearly defined. Ischemic preconditioning (IP) is a powerful mechanism of protection discovered in the several organs such as Heart, Brain and kidney, in which ischemia inconsistently protects the heart cells of myocardium against other ischemic insults. Many factors such as diseases and medications may influence IP expression. Although diabetes poses higher risk, of the stroke in heart & brain, but the physiopathology underlying this condition is uncertain. Moreover, although diabetes causes the endothelial Dysfunction which believed to alter intracellular pathways related to protective mechanisms, by it is still controversial whether diabetes may interfere with ischemic preconditioning and whether this might influence clinical outcomes. This review article looks at published reports with animal models and humans that tried to evaluate the possible influence of diabetes on endothelial as well as ischemic preconditioning of heart.