Abstract

Ashraf A. A. El-Komy*, Enas A. H. Farag and Ahmed M. A. El-Ghazaly

ABSTRACT

The aim of this study was to determine the effect of tylosin (100 ppm) and salinomycin (60 ppm) in feed on liver and kidney function as well as on some heamatological parameters in broiler chicken challenged with necrotic enteritis caused by Clostridium perfringens. Two hundred fifty one-day old chick were divided into 5 groups: non-infected non-treated group, group infected with isolate Clostridium perfringens and non-treated, group infected and administrated with 100 ppm tylosin in feed, group infected and administrated with 60 ppm salinomycin in feed, and group infected and administrated with 100 ppm tylosin and 60 ppm salinomycin in combination. Blood samples were collected at one, 6, 15 days post treatment to investigate the liver and kidney function as well as on some heamatological parameters. The results showed administration of tylosin and salinomycin alone or in combination induced significant increase in liver enzyme activities and significant increase in uric acid and creatinine levels compared to non-infected non-treated group (control group). And induced significant improvement in liver enzymes, protein pictures, serum uric acid and creatinine levels when compared with infected non-treated chickens. And induced significant improvement in both erythrogram and leukogram parameters compared with infected non-treated groups.