Abstract

Mohd Osama Umar, Vaishali Rajput*, Kapil Kumar, Ikram, Aparna Joshi

ABSTRACT

Microemulsions (ME) basically are the mixture of oil, surfactant (SA) and water, with a co surfactant (Co-SA) in different ratio. This mixture is clear and stable. The final prepared fluid possesses low viscosity. ME are isotropic, stable transparent systems of with a droplets diameter>500 nm. Due to small droplets size, they may serve an excellent carrier for drugs having poor water solubility. Terbinafine hydrochloride is derivative of allylamine, and is used orally in the treatment of hepatic failure, neutropenia. Whenever given topically, it is used for the skin infections like jock itch, and for ringworm and Candida species. In the present study an attempt was made to increase solubility of Terbinafine hydrochloride by the means of ME formulations. Prepared formulations were evaluated on different parameters. Study concluded that the means of microemulsions formulations solubility of Terbinafine hydrochloride can be enhanced.