MORUS ALBA LEAVES AQUEOUS EXTRACT PREVENTS THE OXIDATIVE STRESS IN RATS DURING ACUTE LIVER FAILURE
Patil Vishal S.* and Oswal Rajesh J.
ABSTRACT
Acute liver failure (ALF) is the rapid onset of hepatic dysfunction in a patient without known pre-existing liver illness. ALF could result into multi-organ failure (MOF) by causing adverse effects on other organs including spleen, testis, kidney, and brain. Oxidative stress is believed to play central role in the development of MOF; however, effective treatment is not available. Present study was aimed to evaluate whether Morus alba aqueous extract (M.A) has therapeutic potential against oxidative stress in liver, in a thioacetamide (TAA) induced experimental rat model of ALF. In comparison to control groups, liver of rats with ALF showed significant decrease in the activity of antioxidant enzymes such as superoxide dismutase (SOD), catalase, and glutathione reductase (GR), which is followed by rise in lipid peroxidation (LPO) level and fall in total reduced glutathione (GSH) level. On the other hand, treatment of M.A normalised the LPO and GSH levels in liver by activating the most antioxidant enzymes. Findings of the present study suggested that oxidative stress causes adverse effect on TAA induced ALF. M.A has therapeutic role as an effective antioxidant in the treatment of ALF and oxidative damage occurs in liver due to ALF.
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