Abstract

C. Mohana*, K. Manasa, S. Pushpa Sree, N. Priyanka and M. Kishore Babu

ABSTRACT

Polycystic ovary syndrome (PCOS) is an endocrine-gynecology disorder affecting many women of childbearing age. Although a part of the involved mechanism in PCOS occurrence is discovered, the exact etiology and pathophysiology are not comprehensively understood yet. Androgen excess (male hormone excess), seen in 60-80% of girls and women with PCOS, is a key problem in the disorder and likely comes from ovaries in most women. The evidence suggests the several different external and internal factors which includes hyperandrogenism, insulin resistance, genetic, epigenetics and environmental factors. PCOS increases the risk of further complications like anxiety, depression, metabolic syndrome, cardiovascular diseases and type 2 diabetes mellitus, cardiovascular diseases. However, the symptoms can be successfully managed with proper medication and lifestyle interventions. In this review article, about PCOD are clearly explored. Physicians suggested to use anti androgen agents, insulin sensitizers, (combined) oral contraceptives, and ovulation inducers. According to United states food and drug administration (USFDA) there is no medication approved particularly for PCOD and all medications mentioned are off label used.