Abstract

Venkateswara Rao S.*, Renuka Prabhandana N. and Padmalatha K.

ABSTRACT

Nanosuspensions are fine dispersion of uniform-sized solid particles in an aqueous vehicle. Many of the drug candidates are exhibiting poor aqueous solubility. The use of drug nanosuspension is a universal formulation approach to increase the therapeutic performance of these drugs in any route of administration. Nanosuspension consists of the pure poorly water-soluble drug without any matrix material suspended in dispersion. Preparation of nanosuspension is simple and applicable to all drugs which are water insoluble. A nanosuspension not only solves the problems of poor solubility and bioavailability, but also alters the pharmacokinetics of drug and thus improves drug safety and efficacy. This review article describes the preparation methods, characterization, and applications of the nanosuspension.