Abstract

Mahesh Kumar Sharma, Mohit Chadha, Devesh Kumar, Dushyant Kumar Mishra, Anjul Rathi, Vikas Ashokrao Kokare, Amit Sureshrao Sontakke, Agilandeswari Devarajan and Deepak Singh*

ABSTRACT

The most prevalent depigmenting condition, vitiligo, is characterized by white spotson the skin. The pathogenetic basis of vitiligo is the autoimmune destruction ofmelanocytes; oxidative stress, for example, is accountable for the molecular andorganelle dysfunction, exposure to melanocyte-specific antigens, and death ofmelanocytes, and thus plays a significant role in the progression of vitiligo. Inrecent years, a wide range of pharmacological activities for various skin problemshave been proven by natural compounds. This study's primary focus is on theprocesses and effects of natural chemicals against vitiligo models. The pathogeneticbasis of vitiligo is the autoimmune destruction of melanocytes; oxidative stress, forexample, is accountable for the molecular and organelle dysfunction, exposure tomelanocyte-specific antigens, and death of melanocytes, and thus plays a significantrole in the progression of vitiligo. Natural products have demonstrated a broadspectrum of pharmacological bioactivities against several skin disorders in recentyears. This review centers on the processes and effects of natural compoundsagainst models of vitiligo. Research has demonstrated that a few naturally occurringsubstances, including coumarins, glycosides, flavonoids, and phenols, have aprotective function in melanocytes and stop the depigmentation process. Theenormous potential of plants as anti-vitiligo agents is discussed in this paper, alongwith prospective future research areas.