Abstract

Rohit R. Eklare*, Aishwarya D. Bondhare, Sanyuja B. Borkar and Prajwal D. Chakole

ABSTRACT

Vitex negundo linn is large aromatic shrub distributed throughout India. Herbalmedicine, rather than merely curing particular disease, aims at returning the bodyback to its natural state of health. Many traditionally used plants hold importance inmodern days medical regimen as they have been proved scientifically to posses’various activities which are desirable. Vitex negundo belonging to the familyverbenaceae growing in moist or along with water courses. Phytochemicalinvestigation shows the presence of flavonoids, essential oils, flavonoid glycosides,terpenes, lignans, stilbene derivative and iridoid glycosides and possessesenormous, anti-inflammatory, antioxidant, analgesic, antibacterial, antitumor, antiarthritic.The ethanolic extract of vitex negundo roots was screened forphytochemical analysis and revealed the presence of all components. The adult ratswere divided into four groups of six each and maintained under ideal laboratoryconditions. Group I was taken as control and group II treated with the standard drugIndomethacin (10 mg/kg), the ethanolic extract of vitex negundo root 200 mg/kgand 400 mg/kg were fed to group III and IIII. The higher dose group of vitexnegundo root extract (400 mg/kg) were revealed more activity than theircorresponding lower dose.