Abstract

Mukutasab Agasanahalli*, Ganesh N.S, E. Gopinath, J Adlin Jino Nesalin and Vineeth Chandy

ABSTRACT

Self-emulsifying drug delivery (SEDDS) are well-known technique for improvingthe aqueous solubility and oral bioavailability of different classes of drugs. Selfdoubleemulsifying drug delivery system (SDEDDS) is a modified form of selfemulsifyingdrug delivery system (SEDDS) primarily designed to deliver BCSClass III drugs defined as ?high soluble and low permeable? drugs. Gastrointestinalpermeability is the rate-limiting step in the absorption of Class III drugs (highsoluble and low permeable drugs). Hydrophilic drug transport across the intestinalepithelium is primarily restricted to paracellular pathways. However, the limitedsurface area and tight junctions between adjacent cells limit drug transport and areresponsible for the low bioavailability of hydrophilic drugs across the paracellularroute. Small oil globules are absorbed via the lymphatic system bypassing portalcirculation and the hepatic first-pass effect. Drugs that undergo the hepatic first-passeffect also have low bioavailability, which can be improved by absorption andtransport via the lymphatic system. Many methods, including absorption enhancers,chemical modifications, and pharmaceutical means, were used to improve the oralbioavailability of those drugs. Among these approaches, water-in-oil-in-wateremulsions have the greatest potential for increasing the oral bioavailability of BCSClass III drugs. Therefore, increasing the permeability of low permeable drugs mayimprove the bioavailability of ?high soluble and low permeable? drugs i.e., BCSClass III drugs. This review briefly discusses the composition, mechanism,advantages, disadvantages, method of preparation, formulation, and evaluation ofSelf double emulsifying drug delivery system (SDEDDS).