Abstract

Dr. Arivoli D.*and Manoharan A.

ABSTRACT

Introduction: Dyslipidemia is one of the metabolic disorders due to food and lifestyle modifications. It raises the risk of atherosclerosis especially among young people with obesity and diabetes. Dyslipidemia is the common feature of people with type 2 diabetes. The diabetic dyslipidemia is the combination of hyperglycemia, high triglycerides and low level of high-density lipoprotein (HDL) level. Aim: In the present study, the effect of siddha formulation karunjeeraga chooranam was analyzed on level of cholesterol, Triglycerides, High Density Lipoprotein (HDL), Low Density Lipoprotein (LDL), Very Low Density Lipoprotein(VLDL) and Atherogenic Index(AI) and LDL-C/HDL-C ratio in Wister Albino rat models. Materials and Methods: The Siddha formulation Karunjeeragm chooranam was prepared at GSMC, Palyamkottai. The Wister Albino rats were used in this study, weighted and divided into five groups and each group having six rats. In group I, rats were normal control, in group II, fed the cholesterol to the rats at a dose of 400 mg/kg body weight for 30 days. In group III, atorvastatin was fed to rats at a dose of 1mg/kg body weight from day 15 to 30. In group IV, siddha formulation of karunjeeraga chooranam was fed to rats at a dose of 100 mg/kg from 15 days to 30 days. In group V, siddha formulation of karunjeeraga chooranam was fed to rats at a dose of 200mg/kg body weight from days 15 to day 30. At end of the day, all the rats were sacrificed and the blood was collected. Discussion: The results revealed that serum of hyperlipidemic rats showed significant reduction in the higher level of Cholesterol, Triglycerides, LDL - C when compared with normal rats. Karunjeeragan chooranam showed an improvement in the cardio vascular risk level by decrease of Atherogenic Index in the treated group by more than 73% and 63% (p < 0.01), when compared to the cholesterol control group. Results: The result were concluded that, the Siddha formulation karunjeeragan chooranam has the potential effect to reduce the cholesterol, triglycerides, Low Density Lipoprotein(LDL),Very Low Density Lipoprotein(VLDL) and LDL-C/HDL-C ratio.