Abstract

Manisha Bharti*, Ashish Singhai and Dr. Vipin Dhote

ABSTRACT

The present investigation was designed to evaluate the antiarthritic potential ofBaliospermum montanum roots. Baliospermum montanum were defatted bypetroleum ether then successive extraction was done with chloroform, ethanol andwater. Arthritis was induced by complete freund’s adjuvant arthritis assessment wasdone by measuring paw volume, bodyweight, locomotor activity, haematologicalparameter, haemoglobin and erthrocyte sedimentation rate and In vivo antioxidantparameter (lipid peroxidation, superoxide dimutase, glutathione), histopathologicalassessment of joints, Radiological studies. Ethanolic extract of Baliospermummontanum roots significantly inhibition of paw volume, increased locomotoractivity, increased haemoglobin and decreased erythrocyte sedimentation rate anddecreased lipid peroxidation and increased superoxide dimustase and gluthathineHistopathological studies showed less influx of inflammatory cells, no pannusformation and absence of necrosis, radiographic study showed reducing the softtissue swelling and narrowing of joint spaces. The result of the investigationconcluded ethanolic extract of Baliospermum montanum possesses a significantantiarthritic activity. The observed antiarthritic activity may be due to the presenceof phytoconstituent such as flavanoid. However further studies are needed to carryout the isolation of active constituents of ethanolic extract responsible for theactivity.