Abstract

Shruti Jaswal and Rajeev Garg*

ABSTRACT

The primary aim of this research was to improve the solubility and Bioavailability of BCS Class-IV drugs because of their low solubility and Low permeability and dissolution rate. Solubility is one of the important parameter to achieve desired concentration of drug in systemic circulation for therapeutic response to be shown. The aim of research work is to prepare oral dispersible tablets using solid dispersion as a core material. Solid dispersions were prepared by kneading method, physical mixture and solvent evaporation method using varied concentrations of hydrophilic polymer (Cyclodextrins). Dissolution profile predicted that solid dispersion prepared with 1:2 % w/w CP and Cyclodextrins by solvent evaporation has shown highest drug release. Powder blend of all formulations was evaluated for pre-compression parameters (FTIR, Hausner’s ratio, Carr’s index and angle of repose) and it was observed that all excipients were compatible with CP and has excellent flow properties. Dispersible tablets were prepared by direct compression method using different concentration (0, 2.5 and 5 % w/w) of croscarmellose sodium and were evaluated for drug content, weight variation, friability, dispersion time and in vitro drug release studies. Drug content was found to be more than 94 % for all prepared tablets whereas friability and weight variation were below 1 % and 5 % w/w respectively. Tablet formulations containing 5% w/w of croscarmellose sodium showed least dispersion time (2.51 minutes) and highest drug release 96 % in just 30 minutes which was better than marketed formulation (CEFOPROX) as well as pure drug.