Abstract

V. Sowmya* and Dr. A. Rajareddy

ABSTRACT

Benzothiazole is a heterocyclic chemical compound. The aim is to synthesize title compounds by facile synthesis procedure starting from p- substituted aniline & potassium thiocyanate to give 6-substituted 2-amino benzothiazole. Subsequently added substituted benzaldehyde, in chlorine, O-NO2, M-NO2, P-NO2, and OCH3 to give these compounds’ lipophilicity is determined. Our experiment is to determine lipophilicity as it has become a critical parameter in the pharmaceutical industry. This indicates the relationship of a drug with its biological pharmacokinetic and metabolic properties lipophilicity can be measured by the distribution of a drug between the organic phase which is generally n-octanol pre-saturated with water and the aqueous phase as the water it can be experimentally determined by using various methods like shake flask method, potentiometric, and chromatographic methods. The structure of the synthesized compound was confirmed on the basis of spectral studies (U.V, I.R, H.NMR). The lipophilicity parameter of (4-substituted benzylidene -6- substituted benzo[d] thiazol – 2 amine) was determined by using solvents such as n-octanol and benzene, following the shake flask method and titration method. Which was found that the product is distributed greater in the organic phase than in the aqueous phase, which is lipophilic in nature.