Abstract

Priti Anil Waje and Kundan J. Tiwari*

ABSTRACT

Proteins and Peptides which are continuously to grow in the medication for their possible use in the current drug therapy and protein drug market. Peptides are one of the best applicants of drug development due to their higher specificity and lower toxicity. Mostly peptides are obtained from chemical synthesis or other biological technique. The peptide based drugs are use to as a antimicrobial agent as well as cure of cancer. Most of peptides when attach to the Heterocyclic compounds shows most of activity such as antifungal, antimicrobial, antibacterial, anti-inflammatory activity etc. Most of synthetic molecules have been design to prevent the cell proliferation. The widely varieties of the biopeptides has been discovered by the last two decades. In chemical synthesis of peptides, mainly two procedure are used, one is a solid-phase synthesis technique which are carried out on a solid support such as a resin and other also solution phase synthesis technique. Condensation of Heterocyclic component or group like as P-amino salicylic acid (PAS), Coumarin, Nicotinic acid, Furan, Quinoline, Imidazole, Thiazole with a peptide containing amino acid shows potent biological action. In addition to the biological and pharmacological activities of the Dipeptide were examined by prediction of activity spectra for substance (PAAS) Program.